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Ifomula ye-molecular ye-Zolmitriptan: C16H21N3O2

I-Chemical IUPAC Igama: (S)-4-({3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one

Inombolo ye-CAS: 139264-17-8

Ifomula Yesakhiwo:

I-Zolmitriptan

I-Zolmitriptan iyi-agonist ekhethiwe ye-serotonin receptor ye-1B kanye ne-1D subtypes.I-triptan, esetshenziswa ekwelapheni okunamandla kokuhlaselwa yi-migraine noma ngaphandle kwe-aura kanye nekhanda lekhanda leqembu.I-Zolmitriptan iwukwenziwa kokwenziwa kwe-tryptamine futhi ibonakala njengempushana emhlophe encibilika kancane emanzini.

I-Zomig iyi-agonist ye-serotonin (5-HT) ye-receptor esetshenziswa ekwelapheni i-acute migraines kubantu abadala.Isithako esisebenzayo ku-Zomig i-zolmitriptan, i-serotonin receptor agonist ekhethiwe.Ihlukaniswa njenge-triptan, okukholakala ukuthi inciphisa ubuhlungu be-migraine ngokukhulula ukuvuvukala nokunciphisa imithambo yegazi.Njenge-agonist ekhethiwe ye-serotonin receptor, i-Zomig iphinde imise izimpawu zobuhlungu ezithunyelwa ebuchosheni futhi ivimbele ukukhululwa kwamakhemikhali athile emzimbeni abangela izimpawu ze-migraine, okuhlanganisa ubuhlungu bekhanda, isicanucanu, nokuzwela ekukhanyeni nomsindo.I-Zomig ikhonjiswe i-migraines ene-aura noma ngaphandle kwayo, izimpawu ezibonakalayo noma zezinzwa abanye abantu abane-migraines ababhekana nazo ngaphambi kobuhlungu bekhanda.

Ukusetshenziswa kweZolmitriptan

I-Zolmitriptan isetshenziselwa ukwelashwa okunamandla kwe-migraines noma ngaphandle kwe-aura kubantu abadala.I-Zolmitriptan ayihloselwe ukwelashwa kwe-prophylactic ye-migraine noma ukusetshenziswa ekulawuleni i-hemiplegic noma i-basilar migraine.

I-Zolmitriptan itholakala njengethebhulethi egwinywayo, ithebhulethi ehlakazwa ngomlomo, kanye nesifutho samakhala, ngemithamo engu-2.5 no-5 mg.Abantu abaphathwa yimigraines ku-aspartame akufanele basebenzise ithebhulethi ehlakazekayo (Zomig ZMT), equkethe i-aspartame.

Ngokocwaningo lwamavolontiya anempilo, ukudla okudlayo kubonakala kungenamthelela omkhulu ekusebenzeni kweZolmitriptan kokubili kwabesilisa nabesifazane.

I-zolmitriptan eku-Zomig ibophezela kuma-serotonin receptors athile.Abacwaningi bakholelwa ukuthi i-Zomig isebenza ngokubopha kulawa ma-receptors kuma-neurons (amangqamuzana ezinzwa) nasemithanjeni yegazi ebuchosheni, okubangela ukuthi imithambo yegazi ibambene futhi ivimbele amakhemikhali angandisa ukuvuvukala.I-Zomig iphinde yehlise izinto ezibangela ubuhlungu bekhanda futhi ezingase zihileleke kwezinye izimpawu ezivamile ze-migraine, njengesicanucanu, ukuzwela ukukhanya, nokuzwela umsindo.I-Zomig isebenza kahle kakhulu lapho ithathwa uphawu lokuqala lwe-migraine.Ayivimbeli i-migraine noma inciphise inani lokuhlaselwa kwe-migraine onakho.

Imiphumela emibi ye-Zolmitriptan

Njengayo yonke imithi, i-Zomig ingase ibangele imiphumela emibi engahlosiwe.Imiphumela emibi evame kakhulu etholwa abantu abathatha amaphilisi e-Zomig ubuhlungu, ukucinana noma ingcindezi entanyeni, emphinjeni, noma emhlathini;isiyezi, ukudlikiza, ubuthakathaka noma ukungabi namandla, ukozela, imizwa yokufudumala noma amakhaza, isicanucanu, ukuzwa ukuba mkhulu, nomlomo owomile.Imiphumela emibi evame kakhulu etholwa abantu abathatha i-Zomig nasal spray ukunambitheka okungajwayelekile, ukushoshozela, isiyezi, nokuzwela kwesikhumba, ikakhulukazi isikhumba esizungeze ikhala.

Izikhombo

https://en.wikipedia.org/wiki/Zolmitriptan

https://www.ncbi.nlm.nih.gov/pubmed/16412157

https://www.ncbi.nlm.nih.gov/pubmed/18788838

https://www.ncbi.nlm.nih.gov/m/pubmed/10473025

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