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Mokhoa oa molek'hule oa Zolmitriptan: C16H21N3O2

Chemical IUPAC Lebitso: (S) -4-({3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one

Nomoro ea CAS: 139264-17-8

Foromo ea Sebopeho:

Zolmitriptan

Zolmitriptan ke khetho ea serotonin receptor agonist ea 1B le 1D subtypes.Ke triptan, e sebelisoang kalafong e matla ea litlhaselo tsa migraine kapa ntle le aura le hlooho ea hlooho ea sehlopha.Zolmitriptan ke motsoako oa tryptamine oa maiketsetso 'me o hlaha e le phofo e tšoeu e qhibilihang hanyenyane metsing.

Zomig ke serotonin (5-HT) receptor agonist e sebelisoang ho phekola migraine e matla ho batho ba baholo.Motsoako o sebetsang ho Zomig ke zolmitriptan, serotonin receptor agonist e khethiloeng.E hlalosoa e le triptan, eo ho lumeloang hore e fokotsa bohloko ba migraine ka ho imolla ho ruruha le ho fokotsa methapo ea mali.E le khetho ea serotonin receptor agonist, Zomig e boetse e emisa matšoao a bohloko a rometsoeng bokong le ho thibela ho lokolloa ha lik'hemik'hale tse itseng 'meleng tse bakang matšoao a migraine, ho akarelletsa le hlooho e bohloko, ho nyekeloa ke pelo, le kutloisiso ea leseli le molumo.Zomig e bontšoa bakeng sa migraine e nang le aura kapa ntle le eona, matšoao a bonoang kapa a kutlo ao batho ba bang ba nang le migraine ba a utloa pele ho bohloko ba hlooho.

Tšebeliso ea lithethefatsi "Zolmitriptan".

Zolmitriptan e sebelisoa bakeng sa phekolo e matla ea migraine ka kapa ntle le aura ho batho ba baholo.Zolmitriptan ha e reretsoe ho phekola migraine kapa ho sebelisoa ho laola hemiplegic kapa basilar migraine.

Zolmitriptan e fumaneha e le letlapa le ka metsang, letlapa le qhaqhoang ka molomo, le sefafatsi sa nko, ka litekanyetso tsa 2.5 le 5 mg.Batho ba tšoaroang ke migraine ho tsoa ho aspartame ha baa lokela ho sebelisa letlapa le qhala (Zomig ZMT), le nang le aspartame.

Ho ea ka phuputso ea baithaopi ba phetseng hantle, ho ja lijo ho bonahala ho se na phello e kholo katlehong ea Zolmitriptan ho banna le basali.

Zolmitriptan ho Zomig e tlama ho li-receptor tse itseng tsa serotonin.Bafuputsi ba lumela hore Zomig e sebetsa ka ho tlama li-receptor tsena ho li-neurone (liseleng tsa methapo) le methapong ea mali bokong, e leng se etsang hore methapo ea mali e koalehe le ho thibela lik'hemik'hale tse ka eketsang ho ruruha.Zomig e boetse e fokotsa lintho tse bakang mahlaba a hlooho le tse ka amehang matšoao a mang a tloaelehileng a migraine, joalo ka ho nyekeloa ke pelo, kutloelo-bohloko ho khanya, le kutloisiso ea molumo.Zomig e sebetsa hantle ha e nkuoa lets'oao la pele la migraine.Ha e thibele migraine kapa ho fokotsa palo ea litlhaselo tsa migraine tseo u nang le tsona.

Litla-morao tsa Zolmitriptan

Joalo ka litlhare tsohle, Zomig e ka baka litlamorao tse sa lebelloang.Litla-morao tse tloaelehileng ka ho fetisisa tse fumanoang ke batho ba noang matlapa a Zomig ke bohloko, ho tiisa kapa khatello molaleng, 'metso, kapa mohlahare;ho tsekela, ho tsikinyeha, ho fokola kapa ho hloka matla, ho otsela, maikutlo a mofuthu kapa serame, ho nyekeloa ke pelo, ho ba le boima ba 'mele, le molomo o omeletseng.Litla-morao tse atileng haholo tse bonoang ke batho ba nkang Zomig nasal spray ke tatso e sa tloaelehang, ho tsikitlanya, ho tsekela, le kutlo ea letlalo, haholo letlalo le haufi le nko.

Litšupiso

https://en.wikipedia.org/wiki/Zolmitriptan

https://www.ncbi.nlm.nih.gov/pubmed/16412157

https://www.ncbi.nlm.nih.gov/pubmed/18788838

https://www.ncbi.nlm.nih.gov/m/pubmed/10473025

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