Ichi chikamu chehurongwa hwedu huri kuenderera mberi huchibatsira vatengi kunzwisisa zviri nani zvigadzirwa zvemishonga.Isu tinoshandura sainzi yemishonga, tsanangura hunhu hwezvinodhaka, uye tinokupa zano rechokwadi, saka iwe unogona kusarudza iyo yakakodzera mishonga yemhuri yako!

Molecular formula yeZolmitriptan: C16H21N3O2

Kemikari IUPAC Zita: (S) -4-({3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-imwe

Nhamba yeCAS: 139264-17-8

Structural Formula:

Zolmitriptan

Zolmitriptan inosarudza serotonin receptor agonist ye1B uye 1D subtypes.Iyo triptan, inoshandiswa mukurapa kwakanyanya kwekurwiswa kwemigraine ine kana isina aura uye misoro yesumbu.Zolmitriptan inogadzirwa netryptamine inotorwa sehupfu chena inonyungudika zvishoma mumvura.

Zomig is serotonin (5-HT) receptor agonist iyo inoshandiswa mukurapa acute migraines muvakuru.Iyo inoshanda muZomig ndeye zolmitriptan, inosarudza serotonin receptor agonist.Inorondedzerwa se triptan, iyo inofungidzirwa kuderedza marwadzo emigraine nekubvisa kuzvimba uye kuderedza mitsipa yeropa.Sekusarudzwa serotonin receptor agonist, Zomig inomisawo zviratidzo zvinorwadza zvichitumirwa kuuropi uye inovhara kusunungurwa kwemamwe makemikari mumuviri anokonzera zviratidzo zvemigraine, kusanganisira kurwadziwa kwemusoro, kusvotwa, uye kunzwisiswa kwechiedza uye inzwi.Zomig inoratidzirwa kune migraines ine kana isina aura, iyo yekuona kana yekunzwa zviratidzo vamwe vanhu vane migraines vanosangana pamberi pemusoro kurwadziwa.

Kushandisa Zolmitriptan

Zolmitriptan inoshandiswa pakurapa kwakanyanya kwemigraines ine kana isina aura muvakuru.Zolmitriptan haina kuitirwa prophylactic therapy yemigraine kana kushandiswa mukutarisira hemiplegic kana basilar migraine.

Zolmitriptan inowanikwa sepiritsi rinomedzwa, piritsi remuromo rinoparara, uye nemhino yekupfapfaidza, mumiyero ye2.5 uye 5 mg.Vanhu vanobatwa nemigraines kubva kuaspartame havafanirwe kushandisa piritsi rinoparara (Zomig ZMT), iro rine aspartame.

Maererano nekuongorora kwevazvipiri vane hutano, kudya kwekudya kunoratidzika kunge kusina chinhu chakakosha pakubudirira kweZolmitriptan muvarume nevakadzi.

Iyo zolmitriptan muZomig inosunga kune mamwe serotonin receptors.Vatsvaguri vanotenda kuti Zomig inoshanda nekusunga kune aya ma receptors mumaneuroni (nerve masero) uye patsinga dzeropa muuropi, zvichiita kuti tsinga dzeropa dzibate uye kuvharira makemikari anogona kuwedzera kuzvimba.Zomig zvakare inoderedza zvinhu zvinokonzeresa kurwadziwa kwemusoro uye izvo zvingave zvichibatanidzwa mune zvimwe zvinozivikanwa zviratidzo zvemigraine, senge kusvotwa, kunzwa kuchiedza, uye kunzwa inzwi.Zomig inoshanda zvakanyanya kana inotorwa pachiratidzo chekutanga chemigraine.Izvo hazvidziviriri migraine kana kuderedza nhamba yekurwiswa kwemigraine yaunayo.

Side Effects yeZolmitriptan

Kufanana nemishonga yese, Zomig inogona kukonzera zvisingatarisirwe mhedzisiro.Migumisiro yakajairika inowanikwa nevanhu vanotora mapiritsi eZomig kurwadziwa, kuoma kana kumanikidzwa mumutsipa, huro, kana shaya;dzungu, kurira, kupera simba kana kushaya simba, kurara, kunzwa kwekudziya kana kutonhora, kusvotwa, kunzwa kuremerwa, uye muromo wakaoma.Izvo zvinowanzoitika mhedzisiro inowanikwa nevanhu vanotora Zomig nasal spray kuravira kusina kujairika, kurira, dzungu, uye kunzwa kweganda, kunyanya ganda rakatenderedza mhino.

References

https://en.wikipedia.org/wiki/Zolmitriptan

https://www.ncbi.nlm.nih.gov/pubmed/16412157

https://www.ncbi.nlm.nih.gov/pubmed/18788838

https://www.ncbi.nlm.nih.gov/m/pubmed/10473025

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