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Inzira ya molekulari ya Zolmitriptan: C16H21N3O2

IMPAC Izina Izina: (S) -4 - ({3- [2- (Dimethylamino) ethyl] -1H-indol-5-yl} methyl) -1,3-oxazolidin-2-imwe

CAS No.: 139264-17-8

Imiterere yuburyo:

Zolmitriptan

Zolmitriptan ni selotonine yakira reseptor agonist ya 1B na 1D subtypes.Ni triptan, ikoreshwa mukuvura gukabije kwibasirwa na migraine hamwe cyangwa idafite aura na cluster umutwe.Zolmitriptan ni intungamubiri ya tryptamine ikomoka kandi igaragara nkifu yera ibora igice cyamazi.

Zomig ni serotonine (5-HT) reseptor agonist ikoreshwa mukuvura migraine ikaze kubantu bakuru.Ikintu gikora muri Zomig ni zolmitriptan, serotonine yakira reseptor agonist.Ishyirwa muri triptan, ikekwa ko igabanya ububabare bwa migraine mu kugabanya kubyimba no kugabanya imiyoboro y'amaraso.Nka serotonine yakira reseptor agonist, Zomig ihagarika kandi ibimenyetso byububabare byoherezwa mubwonko kandi bikabuza gusohora imiti imwe nimwe mumubiri itera ibimenyetso bya migraine, harimo kubabara umutwe, isesemi, no kumva urumuri nijwi.Zomig yerekanwa kuri migraine ifite cyangwa idafite aura, ibimenyetso biboneka cyangwa byumviro abantu bamwe bafite migraine bahura nububabare bwumutwe.

Gukoresha Zolmitriptan

Zolmitriptan ikoreshwa mukuvura cyane migraine hamwe cyangwa idafite aura mubantu bakuru.Zolmitriptan ntabwo igenewe kuvura prophylactique yo kuvura migraine cyangwa ngo ikoreshwe mu micungire ya hemiplegic cyangwa basilar migraine.

Zolmitriptan iraboneka nkibinini byamira, ibinini bisenya umunwa, hamwe na spray yamazuru, mubipimo bya mg 2,5 na 5 mg.Abantu babona migraine kuva aspartame ntibagomba gukoresha ibinini bisenyuka (Zomig ZMT), birimo aspartame.

Nk’uko ubushakashatsi bwakozwe ku bakorerabushake bazima bubivuga, gufata ibiryo bisa nkaho bidafite ingaruka zikomeye ku mikorere ya Zolmitriptan ku bagabo no ku bagore.

Zolmitriptan muri Zomig ihuza na reseptor zimwe na zimwe.Abashakashatsi bemeza ko Zomig ikora ihuza izo reseptors muri neuron (selile selile) no ku miyoboro y'amaraso mu bwonko, bigatuma imiyoboro y'amaraso igabanuka kandi ikabuza imiti yakongera umuriro.Zomig igabanya kandi ibintu bitera ububabare bwumutwe kandi bishobora kugira uruhare mubindi bimenyetso bikunze kugaragara bya migraine, nko kugira isesemi, kumva urumuri, no kumva amajwi.Zomig ikora neza iyo ifashwe ku kimenyetso cya mbere cya migraine.Ntabwo ibuza migraine cyangwa kugabanya umubare wibitero bya migraine ufite.

Ingaruka Zuruhande rwa Zolmitriptan

Kimwe n'imiti yose, Zomig irashobora gutera ingaruka zitateganijwe.Ingaruka zikunze kugaragara kubantu bafata ibinini bya Zomig nububabare, gukomera cyangwa umuvuduko mwijosi, umuhogo, cyangwa urwasaya;kuzunguruka, gutitira, intege nke cyangwa kubura imbaraga, gusinzira, kumva ubushyuhe cyangwa imbeho, isesemi, kumva uburemere, n'umunwa wumye.Ingaruka zikunze kugaragara kubantu bafata Zomig izuru ni uburyohe budasanzwe, gutitira, kuzunguruka, no kumva neza uruhu, cyane cyane uruhu ruzengurutse izuru.

Reba

https://en.wikipedia.org/wiki/Zolmitriptan

https://www.ncbi.nlm.nih.gov/pubmed/16412157

https://www.ncbi.nlm.nih.gov/pubmed/18788838

https://www.ncbi.nlm.nih.gov/m/pubmed/10473025

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